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Other syndromes that may be associated with cancer
More than 50 genes associated with different types of hereditary cancer and genetic syndromes predisposing to cancer with different inheritance patterns have been reported to date. These genes are included in the hereditary cancer general panel or the main genes involved, cited below, can be chosen. Among them are:
- Fanconi anemia [22 genes]: FANCA, FANCB, FANCC, FANCD1 (BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCJ (BRIP1), FANCI, FANCL, FANCM, FANCN (PALB2), FANCO (RAD51C), FANCP (SLX4), FANCQ (ERCC4), FANCR (RAD51), FANCS (BRCA1), FANCT (UBE2T), FANCU (XRCC2), MAD2L2 (FANCV, REV7), FANCW (RFWD3)
- Beckwith-Wiedemann syndrome [8 genes]: KCNQ1, NSD1, HRAS, GPC3, CDKN1C, DIS3L2, IGF2, GPC4
- Bloom syndrome [1 gene]: BLM
- Cardiofaciocutaneous syndrome [4 genes]: BRAF, KRAS, MAP2K1, MAP2K2
- Tuberous sclerosis [2 genes]: TSC1, TSC2
- Gorlin syndrome [3 genes]: PTCH1, PTCH2, SUFU
- Hemihyperplasia (isolated hemihypertrophy) [2 genes]: Study of the methylation of imprinting centers IC1 (H19) and IC2 (KCNQ1OT1)
- Mutiple cutaneous and uterine leiomyomas [1 gene]: FH
- Familial leiomyomastosis with renal carcinoma [2 genes]: WT1, FH
- Li-Fraumeni syndrome [1 gene]: TP53
- Medulloblastoma and other CNS tumors [19 genes]: APC, BRCA2, CREBBP, DICER1, EP300, NF1, NF2, PALB2, PTCH1, PTEN, SUFU, TP53, RB1, SMARCB1, SMARCA4, SMARCE1, TSC1, TSC2, VHL
- Neurofibromatosis and schwannomatosis [8 genes]: LZTR1, NF1, NF2, PRKAR1A, SPRED1, SMARCB1, SUFU, SMARCE1
- Rasopathies and associated syndromes [25 genes]: A2ML1, BRAF, CBL, EYA4, KRAS, HRAS, LZTR1, MAP2K1, MAP2K2, MAP3K8, MYST4 (KAT6B), NF1, NRAS, RAF1, PTPN11,RASA1, RASA2, RIT1, RRAS, SHOC2, SPRED1, SOS1, SOS2, SYNGAP1, SPRY1
- Hereditary retinoblastoma [1 gene]: RB1
- Rothmund-Thomson syndrome [1 gene]: RECQL4
- Von-Hippel Lindau syndrome [1 gene]: VHL
- Wilms tumor [16 genes]: BRCA2, WT1, TP53, PALB2, BLM, GPC3, CDC73, PIK3CA, DIS3L2, DICER1, BUB1B, GPC4, TRIM37, REST, POU6F2, CTR9
- Xeroderma pigmentosum [9 genes]: DDB2, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, POLH, XPA, XPC
Any case of predisposition towards cancer, as well as any solid tumor, is susceptible of benefiting from our genetic tests. We council you on choosing the genetic test that suits best for each case.
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Other syndromes that may be associated with cancer
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