Hereditary breast and ovarian cancer [23 genes]
The most frequent causes of hereditary breast and ovarian cancer are germinal variants in the BRCA1and BRCA2 tumor suppressors. Likewise, other high-moderate penetrance genes exist, whose genetic effects lead to a predisposition to develop breast and ovarian cancer, such as TP53, PTEN, ATM, PALB2, and CDH1, among others.
- Our experts recommend studying the predisposition for breast/ovarian syndrome through our general panel. Guided analysis in individuals who are of Ashkenazi Jew origin can be considered by starting with BRCA1 and BRCA2. Also, we offer the possibility of evaluating individually each of the genes in the panel.
Priority Genes : Genes where there is sufficient evidence (clinical and functional) to consider them associated with the disease; they are included in the clinical practice guidelines.
Secondary Genes: Genes related to the disease, but with a lower level of evidence or that constitute sporadic cases.
* Candidate Genes: Not enough evidence in humans, but potentially associated with the disease.