Hereditary renal cancer [7 genes]
Even though the majority of renal carcinomas are sporadic, there are hereditary syndromes that are associated to its predisposition, such as Von Hippel-Lindau syndrome (due to mutations in the VHL gene), Birt-Hogg-Dubé syndrome (FLCN gene), hereditary papillary renal cell carcinoma (MET gene), and hereditary leiomyomatosis associated with carcinoma of the renal cells (LH gene).
The genetic study can help carry out a correct differential diagnosis of the pathology and, therefore, not only guide the treatment but also provide a better prognosis approximation. Our recommendation includes a panel of multiple genes taking into account the different syndromes associated with both hereditary prostate cancer and hereditary renal cancer.
Priority Genes : Genes where there is sufficient evidence (clinical and functional) to consider them associated with the disease; they are included in the clinical practice guidelines.
Secondary Genes: Genes related to the disease, but with a lower level of evidence or that constitute sporadic cases.
* Candidate Genes: Not enough evidence in humans, but potentially associated with the disease.