Hereditary gastric cancer [15 genes]
When there is a suspicion of hereditary gastric cancer it is recommended to analyze all the genes implicated in hereditary syndromes such as hereditary diffuse gastric cancer (HDGC), Lynch syndrome, familial adenomatous polyposis, polyposis associated with MUTYH, or hereditary breast and ovarian cancer syndrome. HDGC represents 1-3% of all gastric cancers. Germinal mutations in CDH1 have been identified in up to 50% of families with HDGC clinical criteria, with a dominant autosomal inheritance pattern.
Priority Genes : Genes where there is sufficient evidence (clinical and functional) to consider them associated with the disease; they are included in the clinical practice guidelines.
Secondary Genes: Genes related to the disease, but with a lower level of evidence or that constitute sporadic cases.
* Candidate Genes: Not enough evidence in humans, but potentially associated with the disease.