It includes diseases that can cause ventricular arrhythmias and sudden death as their first clinical manifestation. Therefore channelopathies and some genes associated with cardiomyopathies but capable of producing ventricular arrhythmias without any apparent cardiac involvement are included.
This panel is mainly oriented at diagnosing of phenotypes that present ventricular arrhythmias as a primary manifestation of the disease without apparent structural heart disease and not clearly defined phenotype.
It is intended for those individuals whose clinical or anatomopathological study does not show structural alterations, and would be the testing of choice in cases of sudden death with negative autopsy.
It should be especially considered in patients with personal or family history of sudden death, subjects with a history of syncope of undetermined origin, or individuals with idiopathic ventricular fibrillation without structural heart disease.
This panel includes priority genes that have a clear association with these diseases, secondary genes where there is a lesser degree of evidence, and candidate genes gathered from a systematic literature review.
Priority Genes : Genes where there is sufficient evidence (clinical and functional) to consider them associated with the disease; they are included in the clinical practice guidelines. Secondary Genes: Genes related to the disease, but with a lower level of evidence or that constitute sporadic cases. * Candidate Genes: Not enough evidence in humans, but potentially associated with the disease.
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