Atrial fibrillation (AF) is a common heart arrhythmia in the general population with prevalence increasing with age, affecting nearly 6% of individuals over 65 years. There are many cardiac conditions that may predispose to the development of this arrhythmia, although it was observed in the recent years that genetics may be the cause in 5%-15% of cases diagnosed with isolated AF.
Patients with a family history of atrial fibrillation in the absence of predisposing factors such as hypertension, ischemic cardiomyopathy, or structural heart diseases.
The probability of finding a pathogenic
mutation when a patient presents
atrial fibrillation has not been clearly
established. The yield could be higher
in cases where there is a family history
of this disorder and when it occurs in
young subjects without a clear cause.
The panel includes genes with clinical and functional evidence of association with familial atrial fibrillation.
Many of the included genes are associated with defined electrophysiological phenotypes or even structural heart diseases in which the development of atrial fibrillation may be the first or the main manifestation of the disease. This allows for differential diagnosis of familial atrial fibrillation.
Priority Genes : Genes where there is sufficient evidence (clinical and functional) to consider them associated with the disease; they are included in the clinical practice guidelines. Secondary Genes: Genes related to the disease, but with a lower level of evidence or that constitute sporadic cases. * Candidate Genes: Not enough evidence in humans, but potentially associated with the disease.
2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. January CT, et al. Circulation. 2014 Dec 2;130(23):2071-104.
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